ea0065p146 | Endocrine Neoplasia and Endocrine Consequences of Living with and Beyond Cancer | SFEBES2019
Vennard Hannah
, Maniam Pavithran
, Berg Jonathan
, Goudie David
, Newey Paul
Background: Advances in next-generation sequencing facilitate the simultaneous evaluation of large numbers of cancer predisposition genes (CPGs) in patients with cancer irrespective of family history or tumour phenotype. Several studies have reported the frequent occurrence of germline mutations in CPGs in patients with discordant cancer types raising the possibility of novel gene-cancer associations. The current study aimed to evaluate the significance of germline mutations i...